IMPROVED METHODS OF DELIVERY USING CATIONIC LIPIDS AND HELPER LIPIDS

摘要

Methods and compositions are provided for the introduction of polyanionicmolecules, in particular, nucleic acids, into mammalian cells using certainphosphatidyl ethanolamines as helper lipids in conjunction with variouscationic lipids. In particular, cationic lipid-mediated transfection ofmammalian cells is improved by the use of lipid carriers comprising DLPE orDiPPE and cationic lipids.