Yeast artificial chromosomes for studying aberrant proto-oncogene transcription

摘要

The present invention relates to a yeast artificial chromosome (YAC) which comprises a gene activation element and a proto-oncogene or oncogene which is activated by the gene activation element. In particular, the gene activation element is, or is from, an immunoglobulin locus. The invention also relates to cells which have the YAC integrated into their genome, chimeric or transgenic animals derived from such cells and the use of such YACs, cells and animals to investigate the role of tumour formation, in particular B-cell lymphomas.