IMIDAZOLE DERIVATIVES AS PROTECTIVE AGENTS IN REPERFUSION INJURY AND SEVERE INFLAMMATORY RESPONSES

摘要

The invention relates to derivatives of imidazole compounds which are particulary useful as pharmaceuticals. The compounds may be used to inhibit damage to a variety of mammalian tissue that are jeopardized, for example, during runaway inflammatory conditions due to the damaging presence of singlet oxygen, the hydroxyl radical, cytokines and growth factors. The compounds are also useful in inhibiting damage to cardiac and central nervous system tissues during reperfusion.