IDENTIFICATION OF SHORT PEPTIDE SEQUENCES REPRESENTING EPITOPES OF GLYCOPROTEIN G OF HSV-2 USING A PHAGE PEPTIDE DISPLAY LIBRARY

摘要

The invention provides a polypeptide consisting of 3 to 38 amino acid residues, having the sequence of SEG ID:1 or a portion thereof; and analogous polypeptide derivatives by virtue of point mutation, amino acid substitution, deletion or addition; SEQ ID:1 = A?1PPP4PE6H7R8GGPEEF14EGAGDG20 EPP23¿EDDDSATGLAFRTPN38 wherein the sequence includes histidine residue H7; and wherein E6 may be substituted in order of preference by D6 T6; and wherein R8 may be substituted by A8; which sequence is recognised by anti-gG2 positive human sera from patients with HSV-2 infection and is not recognised by anti-gG2 negative sera from patients with HSV-1 infection; and antibodies raised thereto; and prophylactic and therapeutic and diagnostic uses thereof relating to HSV-2 infection.