MCP-3, RANTES AND MIP-1ALPHA RECEPTOR ANTAGONISTS

摘要

The present invention is directed towards NH2-terminally truncated analogs of three human chemokines: MCP-3, RANTES and MIP-1α having highly potent anti-inflammatory activity and anti-autoimmune activity. The present invention is also directed to inhibiting the biological activities of three native, mammalian chemokines: MCP-3, RANTES and MIP-1α. The present invention is further directed to treating inflammatory diseases and autoimmune disorders such as rheumatoid arthritis, for example. The present invention is also directed to pharmaceutical compositions comprising NH2-terminally truncated chemokine analogs.