MODIFIED HUMAN TNFALPHA (TUMOR NECROSIS FACTOR ALPHA) RECEPTOR

摘要

PCT No. PCT/GB91/01826 Sec. 371 Date May 10, 1993 Sec. 102(e) Date May 10, 1993 PCT Filed Oct. 18, 1991 PCT Pub. No. WO92/07076 PCT Pub. Date Apr. 30, 1992A polypeptide is provided which is capable of binding human TNF alpha and which has the first three cysteine-rich subdomains, but not the fourth cysteine-rich subdomain, of the extracellular binding domain of a receptor selected from the group consisting of the 55 kD and 75 kD receptors for human TNF alpha . The ability of the polypeptide to bind TNF alpha means that it can be used for treating diseases mediated by TNF alpha activity, such as rheumatoid arthritis.