Indole Derivatives Useful in the Treatment of Osteoporosis (Indole Derivatives Useful in the Treatment of Osteoporosis)

摘要

Claims 1. A compound of the general formula (I) or a salt thereof or a solvate thereof; Processes for preparing the compounds, pharmaceutical compositions comprising the compounds and uses of the compounds in medicaments.;Formula I;In the above formula;(i) R _a represents a R ₅ group which is hydrogen, alkyl or optionally substituted aryl, R _b represents a moiety of the formula (a);A;In this formula,;X represents a hydroxy or an optionally substituted or unsubstituted alkoxy group, or X represents a NR _s R _t group wherein R _s and R _t are each independently hydrogen, alkyl, substituted alkyl, optionally substituted al An optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or R _s and R _t together may form a heterocyclic group; R ₁ is alkyl or a substituted or represents a non-substituted aryl; R ₂ , R ₃ and R ₄ each independently represent hydrogen, alkyl, aryl or substituted aryl, or;(ii) R _a represents a residue of the above defined formula (a) and R _b represents R ₅ as defined above;;R ₆ and R ₇ are each independently hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro , Alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R ₆ and R ₇ together represent methylenedioxy, carbonyldioxy or carbonyldiamino,;R ₈ represents hydrogen, hydroxy, alkanoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamoyl or aminosulfonyl.