Compositions for improving osteolysis and metastasis (COMPOSITION TO AMELIORATE OSTEOLYSIS AND METASTASIS)

摘要

The present invention also relates to a method of treating or preventing a disease or condition selected from the group consisting of PTHrp, TGF , IL-1 , IL-1 beta, IL-6, lymphotoxin, TNF, PGE; 1,25 dihydroxyvitamin D₃And their antigenic fragments, for the treatment of osteolysis and their symptomatic sequelae, as well as cancer metastasis to bone and cancer cell growth in bone. Antibodies that immunoreact with the parathyroid hormone-related protein (PTHrp) are particularly preferred. Antibodies with human characteristics are included in the present invention to apply the method of the present invention to a human patient. The antibody may also be administered as an injectable preparation in combination with a therapeutically effective amount of a bisphosphonate or pyrophosphonate of general formula 1 and pharmaceutically acceptable salts, hydrates and partial hydrates thereof, wherein X is a phospho It is the part of the connection that allows the interconnections of the name servers. The antibodies and bisphosphonates act synergistically in the treatment of metastasis to the bone and their symptomatic sequelae and, in particular, bone resorption.