N-aryl and N-heteroaryl-1,2-diaminocyclobutene-3,4-diones with smooth (N-Aryl and N-heteroaryl-1,2-diaminocyclobutene- muscle relaxing activities)

摘要

A compound of formula (I) or a pharmaceutically acceptable salt thereof.;Wherein R ₁ is hydrogen, C _1-10 linear or branched alkyl, C _3-10 cyclic or acyclic alkyl, C 2-7 alkanoyl, C 1-7 alkylsulfonyl, C 7-12 Arylalkanoyl having 9 to 20 carbon atoms, arylsulfonyl having 6 to 12 carbon atoms, arylalkanoyl having 8 to 12 carbon atoms or arylalkylsulfonyl having 7 to 12 carbon atoms; R ₂ is hydrogen, C _1-10 linear or branched alkyl or C _3-10 cyclic or acyclic alkyl; A is a group Wherein R ₇ and R ₈ are independently of each other selected from the group consisting of cyano, nitro, amino, C _1-6 alkyl, C _1-6 perfluoroalkyl, C _1-6 alkoxy, C _1-6 perfluoroalkoxy, Amino, C _1-12 mono- or dialkylamino, sulfonamido, C _1-6 alkylsulfonamido, C _6-12 arylsulfonamido, C _2-6 alkylcarboxamido, C _7-12 arylcar carboxamide amido, C _1-6 alkylsulfonyl, C _1-6 alkylsulfonyl as a perfluoroalkyl, C _6-12 arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl, Carboxyalkoxy of 2 to 7 carbon atoms, hydroxyl or hydrogen), or A is Het is; Wherein R ₉ is selected from the group consisting of hydrogen, C _1-6 alkyl, C _1-6 perfluoroalkyl, C _1-6 alkoxy, C _1-6 perfluoroalkoxy, amino, C _1-12 mono- or dialkylamino , C _1-6 alkylsulfonamido, C _2-6 alkylcarboxamido, nitro, cyano, carboxyl, chloro, bromo, fluoro or iodo; n is an integer from 0 to 6; R ³ and R ⁴ are, independently of each other, hydrogen, C _1-10 linear or branched alkyl or C _3-10 cyclic or acyclic alkyl; C _1-10 perfluoroalkyl, C _1-10 hydroxyalkyl, C _2-10 alkoxyalkyl, fluoro; Or together form a spirocyclic ring having 3 to 7 total carbon atoms; R ⁵ and R ⁶ independently of each other are selected from the group consisting of cyano, nitro, amino, C _1-6 alkyl, C _1-6 perfluoroalkyl, C _1-6 alkoxy, C _1-6 perfluoroalkoxy, amino, C _{1 - 12} mono- or dialkylamino, sulfonamide, C _1-6 alkyl sulfonamido, C _6-12 aryl sulfonamido, C _2-6 alkyl, carboxamido, C _7-12 aryl carboxamido , C _1-6 alkyl sulfonyl, alkyl sulfonyl, C _6-12 arylsulfonyl, chloro, bromo, fluoro C _1-6 perfluoroalkyl, iodo, 1-imidazolyl, carboxyl, C _{2- 7} carboalkoxy, hydroxyl or hydrogen.