CONDENSED THIAZOLE DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION SHOWING 5-HT₃-RECEPTOR ACTIVITY BASED ON THEREOF

摘要

FIELD: organic chemistry. SUBSTANCE: invention proposes the condensed derivative of thiazole as 5-HT₃-receptor of the formula (I): , or its pharmaceutically acceptable salt, and its pharmaceutical composition where R - hydrogen, halogen atom, hydroxyl group, lower alkoxy-group, carboxy-group, lower alkoxycarbonyl-group, nitro-, amino-, cyano-group or the protected hydroxyl group; A - phenyl ring or naphthalene ring; L₁ and L₂ - one is a direct bond and another one - linear or branched lower alkylene group that can involve interrupting oxygen or sulfur atom or lower alkenylene group; L - direct bond or linear or branched lower alkylene group; I_m - group of the formula: or where R¹,R² and R³ are similar or distinct one from another and each means hydrogen atom or lower alkyl group; R⁴,R⁵ and R⁶ are similar or distinct one from another and each means hydrogen atom or lower alkyl group. EFFECT: improved method of synthesis. 5 cl, 2 tbl