STRAIN OF VIRUS INFLUENZA B (LENINGRAD) 14/76/50 DESIGNED FOR PREPARING HARMLESS AND HIGHLY PRODUCTIVE INFLUENZA VIRUS B FOR INACTIVATED AND LIVE INFLUENZA VACCINE PRODUCTION

摘要

FIELD: medicine, virology, immunology. SUBSTANCE: strain of virus B (Leningrad)/14/76/50 is obtained by method of serial passages at optimal and infraoptimal incubation temperatures followed by cloning by method of limiting dilutions in chicken fibroblast culture. The obtained strain shows high reproduction: hemagglutinating and infectious activities are 1:(1024-2048) AE and lgEID₅₀/0.2 ml at 32 C and 1:1024 AE and 4.5-5.0 lgEID₅₀/0.2 ml at 26 C, respectively. EFFECT: strain indicated above, enhanced effectiveness.