METHOD OF PREPARING 7,7-DIOXIDE 5,6-DIHYDRO (S) -4- (ALKILAMINO)-(S)-6- ALKYL-4H- THIENO (2,3-b) THIOPYRAN - 2-SULFONAMIDE AND 7,7-DIOXIDE 5,6-DIHYDRO(S)-4- (ACYLAMIDO)-(S)-6-ALKYL-4H-THIENO (2,3-b)THIOPYRAN

摘要

FIELD: pharmaceutical industry. SUBSTANCE: 7,7-dioxide 5,6-dihydro-4- (ethylamino)-6- methyl-5H- thieno (2,3-b) thiopyran sulfonamide is prepared by reacting 7,7-dioxide thieno (2,3-b) thiopyran hydroxyderivative with acetonitrile followed by addition of sulfonamide group to second position of heterocyclic system. The claimed method make it possible to carry out synthesis to retain molecule chirality. The above-mentioned compound is useful in pharmacology for regulating intra pressure. EFFECT: improved properties of the title compounds. 9 cl