ENANTIO-SELECTIVE SYNTHESIS OF 5,6-DIHYDRO-(S)-4- (ETHYLAMINO)-(S)-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN- 2-SULFONAMIDE 7,7-DIOXIDE AND ITS RELATED COMPOUND

摘要

A key step in the synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran- 2-sulfonamide 7,7-dioxide (dorzolamide) and related compounds is a Ritter reaction with an unexpected tendency to proceed with retention of chirality.