A method for the production of n - carboxyalkyl - 3 - fluorine - 4 - dialkyl amino anilines and n - carboxymethyl - 3 - fluorine - 4 - morpholino aniline and n - carboxyl isobutyl - 3 - fluorine - 4 - morpholino aniline

摘要

process for the production of n - carboxyalkyl 3 fluorine - 4 - dialkylaminoanilinen, characterized that in a first step 2 - chloro - 45 - difluornitrobenzol of formula (i) with a secondary amine $f1 formula (ii) hnr1r2,wherein r1 and r2 independently the same or different, and for a alkylrest with 1 to 10 carbon atoms or together with the n atom to which they area ring 5 to 7 are formed in the presence of a water soluble amin.the reaction temperature and aufarbeitungstemperatur liquid and reaktionsgemisch soluble hydrofluoride and hydrochloride isin the presence or absence of a solvent at - 10 to 120 implementsin a second step, the 2 - chloro - 4 - dialkylamino - 5 - fluornitrobenzol reaktionsgemisch containing in the presence of the water soluble amin in the presence of a edelmetallkatalysators with hydrogenin 30 to 150 c and 1 to 350 bars, and in a third step, the 3 - 4 dialkylaminoanilin reaktionsgemisch containing fluorine in the presence of the water soluble amin with a chlorameisensu00e4ureester of formula (iv) clco2r3, wherein r3 is a 1 to 10 carbon atoms or alkylrest aralkylrest with 7 to 20 carbon atoms, with 0 to 100 implements.