首页> 外国专利> Conjugates peptide, their use as an example of the medicinal product and compositions containing them,

Conjugates peptide, their use as an example of the medicinal product and compositions containing them,

机译:结合肽,它们作为医药产品和包含它们的组合物的实例的用途,

摘要

Peptide conjugates including a sequence of at least three amino acids selected from Lys-Lys-Gly, Gly-His-Lys and Glu-His-Lys, wherein "Lys" is Lysine or a halogenated derivative thereof, or a methylated Lysine derivative, particularly Methyl-Lysine and Dihydrobromo-Methyl-Lysine, said amino acids optionally being in D, L or DL form, and said sequence being chemically or physically conjugated with at least one compound selected from monocarboxylic acids of general formula (I): HOOC-R, or alcohol, aldehyde or amide derivatives thereof, and dicarboxylic acids of general formula (II): HOOC-R1-COOH, are disclosed. The use of such conjugates as a drug, and pharmaceutical or cosmetic compositions containing said conjugates, are also disclosed.
机译:肽缀合物,其包含选自Lys-Lys-Gly,Gly-His-Lys和Glu-His-Lys的至少三个氨基酸的序列,其中“ Lys”是赖氨酸或其卤代衍生物,或甲基化的赖氨酸衍生物,特别是甲基赖氨酸和二氢溴甲基赖氨酸,所述氨基酸任选地为D,L或DL形式,并且所述序列与至少一种选自通式(I)的单羧酸的化合物化学或物理缀合:HOOC-R公开了通式(II)的醇,醛或其酰胺衍生物和二羧酸:HOOC-R1-COOH。还公开了这种缀合物作为药物的用途,以及包含所述缀合物的药物或化妆品组合物。

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