Methods for coating metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same

摘要

Improvements in the existing procedures and materials for conduct of high gradient magnetic separation (HGMS) are disclosed. Superior superparamagnetic particles, optionally coated with a polysaccharide or other, usually organic, materials can be prepared in uniform compositions with homogeneous magnetizations. The coating can conveniently be conjugated to a specific binding moiety complementary to a biological material whose purification or separation is desired. In addition, plastic coated matrices which form superior magnetic gradient- intensifying supports are disclosed, along with improved methods and apparatus to conduct HGMS.