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Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
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机译:苯二氮卓衍生物及其作为胆囊收缩素和/或胃泌素受体拮抗剂的用途
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##STR1## Compounds of formula (I), and salts and prodrugs thereof, wherein X is O,S,NR.sup.4 or CH.sub.2 ; R.sup.1 represents H, certain optionally substituted C.sub.1-6 alkyl, or C.sub.3-7 cycloalkyl; R.sup.2 represents phenyl having certain optional substituents; R.sup.3 represents C.sub.1-6 alkyl, halo or NR.sup.6 R.sup.7 ; m is 2,3 or 4; n is 1,2,3,4,5,6 7 or 8 when X is CH.sub.2 or 2,3,4,5,6,7 or 8 when X is O, S or NR.sup.4 ; and x is 0,1,2, or 3; are CCK and/or gastrin antagonists. They and compositions thereof are therefore useful in therapy.
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机译:式(I)的化合物,及其盐和前药,其中X是O,S,NR 4或CH 2; R 1代表H,某些任选取代的C 1-6烷基或C 3-7环烷基; R 2代表具有某些任选取代基的苯基; R 3代表C 1-6烷基,卤素或NR 6 R 7; m是2,3或4;当X是CH.sub.2时n是1,2,3,4,5,6 7或8或X是O,S或NRsup 4时n是2,3,4,5,6,7或8 ; x是0,1,2或3;是CCK和/或胃泌素拮抗剂。因此,它们及其组合物可用于治疗。
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