首页>
外国专利>
Osteoarthritis-associated inducable isoform of nitric oxide synthetase
Osteoarthritis-associated inducable isoform of nitric oxide synthetase
展开▼
机译:骨关节炎相关的一氧化氮合酶诱导型亚型
展开▼
页面导航
摘要
著录项
相似文献
摘要
An novel isoform of inducible nitric oxide synthase (OA-NOS) has been identified in osteoarthritis-affected articular cartilage. Some properties, including molecular weight, are similar to the constitutive isoform of neuronal nitric oxide synthase (ncnos) while other properties share similarity with the previously identified inducible nitric oxide (iNOS). Acetylating agents, such as aspirin and N-acetylimidazole act on both iNOS and OA-NOS by inhibiting their catalytic activities. A method is provided to screen for acetylating agents that inhibit OA-NOS, and the selective inhibition of OA-NOS by inhibitory agents is determined by comparison to a panel of different isoforms of nitric oxide synthase.
展开▼