Identification and isolation of new genes of a bacterial multiple antibiotic resistance regulon

摘要

Methods of identifying loci and isolating genes of a bacterial multiple antibiotic resistance regulon are disclosed. In addition, isolated nucleic acids of three new genes, designated mlr1, mlr2 and mlr3, of the bacterial multiple antibiotic resistance regulon are disclosed and enabled. Transformed bacterial cells with altered expression of these new genes and methods for their use in evaluating potential antimicrobial or antibiotic compounds are also provided. Purified proteins encoded by these genes and antibodies to those proteins are also provided.