Sevenmer cyclic peptide inhibitors of diseases involving amp;agr;. sub.v . beta..sub.3

摘要

The present invention includes non-RGD, nine amino acid cyclic peptides that inhibit the function of the integrin receptor, &agr;.sub. v &bgr;.sub.3. These peptides display surprisingly potent antagonist activity despite the lack of the consensus binding sequence Arg-Gly-Asp, and present opportunities for selective targeting to the &agr;.sub.v . beta..sub.3 receptor. Pharmaceutical compositions and methods of use are also disclosed. The therapeutic uses for the inventive peptides include treating diseases involving &agr;.sub.v &bgr;.sub.3 receptors such as osteoporosis, restenosis, and angiogenic-based diseases, including cancer, arthritis, and diabetic retinopathy.