Tryptophan derivatives as protein tyrosine kinase blockers and their use in the treatment of neoplastic diseases

摘要

Tryptophan derivatives substituted by a hydrophobic group, e.g. carbobenzoxy, at the N-terminus, and a hydrophilic group, e.g. --COOH, -- SO.sub.3 H or --PO.sub.3 H, at the C-terminus, were found to be cell- permeable blockers of protein tyrosine kinases (PTKs). These PTK blockers are useful in basic research and in the treatment of neoplastic diseases.