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DNA sequencing, mapping, and diagnostic processes using hybridization and stable isotope labels of DNA
DNA sequencing, mapping, and diagnostic processes using hybridization and stable isotope labels of DNA
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机译:使用DNA的杂交和稳定同位素标记进行DNA测序,作图和诊断过程
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摘要
A DNA sequencing, mapping, and diagnostic process which includes the steps of labeling nucleotide segments or peptide nucleic acids (PNAs) with one or more atoms of specific stable or long-lived radioactive isotopes of a selected element that do not normally occur in DNAs, ODNs or PNAs such that the nucleotide segment or PNA has specific stable or long-lived radioactive isotope of a specified selected element at a terminal or an interior position; hybridizing the labeled nucleotide segment or PNA to complementary nucleic acid segments or PNAs which are fixed on a hybridization surface; and, using mass spectrometric techniques, including RIS, to analyze the presence and position of the labeled hybridized nucleotide segments or PNAs which are bound to the fixed nucleotide segments or PNAs.
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