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Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
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机译:ICAM-1,E-选择素和CMV IE1 / IE2的反义抑制
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摘要
Compositions and methods are provided for inhibiting the translation of a capped target mRNA. Antisense oligomers of the invention are targeted to the 5' cap region of the target mRNA and include oligonucleosides, PNAs, or oligonucleotides modified at the 2' position of the sugar. Preferably said oligomers inhibit protein translation directly via interference with ribosome assembly.
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