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Indocarbocyanine and benzindocarbocyanine phosphoramidites

机译:吲哚并花菁和苯并吲哚并花菁亚磷酰胺

摘要

A chemical compound of the following formula is disclosed: ##STR1## where R is selected from the group consisting of H, trityl, 4-O- monomethoxytrityl, 4,4'-O-dimethoxytrityl, and acyl groups, and whereby R can be used as a protecting group or is an H;PPR' is a phosphoramidite;PPR" is selected from the group consisting of H and lower alkyl groups;PPR'" is selected from the group consisting of H and lower alkyl groups;PPR. sup.4 is selected from the group consisting of H, lower alkyl, acyl, ##STR2## and (CH.sub.2).sub.p COO(CH. sub.2).sub.q CH.sub.3 wherein p is an integer from 0 to 4 and q is an integer from 0 to 4;PP R.sup.5 is selected from the group consisting of H, lower alkyl, acyl, ##STR3## and (CH.sub.2).sub.p COO(CH.sub.2).sub. q CH.sub.3 wherein p is an integer from 0 to 4 and q is an integer from 0 to 4;PP n is an integer from 0 to 10;PPm is an integer from 0 to 10;PPr is 1, 2, or 3; andPPX.sup.- is a negative ion.
机译:公开了下式的化合物:其中R选自H,三苯甲基,4-O-单甲氧基三苯甲基,4,4'-O-二甲氧基三苯甲基和酰基,其中R可以用作保护基或为H; P

R'为亚磷酰胺;

R“选自H和低级烷基;

。 sup.4选自H,低级烷基,酰基,## STR2 ##和(CH.sub.2)sub.p COO(CH.sub.2).q CH.sub。 3,其中p是0至4的整数,q是0至4的整数; P <R> R 5选自H,低级烷基,酰基,## STR3 ##和(CH.sub.2)sub.p COO(CH.sub.2).sub。 q CH.sub.3,其中p是0到4的整数,q是0到4的整数;

n是0到10的整数;

m是整数从0到10;

r是1、2或3; P P X X-为负离子。

著录项

  • 公开/公告号US5808044A

    专利类型

  • 公开/公告日1998-09-15

    原文格式PDF

  • 申请/专利权人 PHARMACIA BIOTECH INC.;

    申请/专利号US19970799593

  • 发明设计人 ERIC DEAN ANDERSON;CHARLES K. BRUSH;

    申请日1997-02-10

  • 分类号C07H21/00;C12Q1/68;

  • 国家 US

  • 入库时间 2022-08-22 02:38:39

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