There are described stable, non-leaching chiral stationary phases in which a chiral polysaccharide or polysaccharide derivative is covalently bound through a spacer to the surface hydroxyl groups of a refractory inorganic oxide. The spacer molecules are omega- isocyanatoalkylene silanes. Favored refractory inorganic oxides are alumina and silica gel. Cellulose esters and cellulose phenyl carbamates are among the most favored of the chiral polysaccharides.
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