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Methods of using them to kill or image the cells with hormone receptors and hormone analogs containing boron
Methods of using them to kill or image the cells with hormone receptors and hormone analogs containing boron
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机译:用它们杀死含有硼的激素受体和激素类似物以杀死细胞或使其成像的方法
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摘要
(57) responds to the hormone by [Abstract] boron-containing compound, contacting the cell with a complex consisting of boron containing moiety is conjugated to a ligand that has binding specificity for an intracellular receptor of a cell It is targeted to the cell. The complex is used for killing or imaging the cells in response to hormones such as tumor cells can respond to the hormone. To kill target cells, contacting said cell with a 10 B containing moiety is conjugated to a ligand that has binding specificity for an intracellular hormone receptor of the cells.10 B containing moiety binds to a hormone receptor portion of the cells and then kill the cells by boron neutron capture by irradiation with neutrons it. In order to image the target cells, then contacting the cell with a 11 B containing moiety is conjugated to a ligand that has binding specificity for an intracellular hormone receptor of the cells, then bind to the hormone receptor of the cell and imaged using magnetic resonance imaging techniques boron you.
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