New 'burst-free' sustained release poly (lactide / glycolide) microspheres
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机译:新的“无爆裂”缓释聚(丙交酯/乙交酯)微球
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摘要
Novel burst-free, sustained release biocompatible and biodegradable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.
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