High-molecular quantitative surface protein of nontaipuaburuhemohuirusu

摘要

PCT No. PCT/US94/02550 Sec. 371 Date Dec. 13, 1995 Sec. 102(e) Date Dec. 13, 1995 PCT Filed Mar. 15, 1994 PCT Pub. No. WO94/21290 PCT Pub. Date Sep. 29, 1994High molecular weight surface proteins of non-typeable Haemophilus influenzae which exhibit immunogenic properties and genes encoding the same are described. Specifically, genes coding for two immunodominant high molecular weight proteins, HMW1 and HMW2, have been cloned, expressed and sequenced, while genes coding for high molecular proteins HMW3 and HMW4 have been cloned, expressed and partially sequenced.