NEW 2-FLUORO-3-DE((2,6-DIDEOXY-3-C-METHYL-3-O-METHYL-ALPHA-L-RIBOHEXOPYRANOSYL)OXY)-6-O-METHYL-3-OXOERYTHROMYCIN DERIVATIVE, ITS PRODUCTION AND ITS USE FOR SYNTHESIZING ACTIVE INGREDIENT OF MEDICINE

摘要

PROBLEM TO BE SOLVED: To obtain the subject new derivative useful as a synthetic raw material for an active ingredient of a medicine, etc., comprising a specific 2-fluoro-3- oxoerythromycin derivative prepared by treating a 3-oxoerythromycin derivative with an electrophilic fluorinating agent. ;SOLUTION: This new 2-fluoro-3-[(2,6-dideoxy-3-C-methyl-3-O-methyl--L- ribohexopyranosyl)oxy]-6-O-methyl-3-oxoerythromycin derivative is shown by formula I (A is OH group and B forms a carbon-carbon double bond with a carbon atom at the 10-position or A and B are bonded to form a carbonate or a carbamate; OZ is a free esterified or etherified hydroxyl group). The compound is obtained by treating a compound of formula II with an electrophilic fluorinating agent such as N-fluoro-bis(phenylsulfonyl)imide or the like.;COPYRIGHT: (C)1999,JPO