ANTIBODY CONTAINING GRANULOCYTE COLONY-STIMULATING FACTOR INDUCTION ACTIVITY AND ITS MEDICINE

摘要

PROBLEM TO BE SOLVED: To obtain the subject new antibody comprising an antibody having granulocyte colony stimulating factor(G-CSF) induction activity or its part, having G-CSF production ability, useful as a preventive, a therapeutic agent, etc., for adverse effects of anti-cancer agent, opportunistic infectious disease, etc. ;SOLUTION: This antibody or its part has granulocyte colony stimulating factor (G-CSF) induction activity, G-CSF production ability dependently upon concentration, shows treating effects on neutropenia and neutropenia after bone marrow transplantation and apastic anemia and is useful for preventing and treating various infectious diseases including opportunistic infection, etc. The antibody is obtained by administering mouse macrophage cell strain RAW 264.7 as an immunization antigen to an MRL/1 pr mouse by intraperitoneal administration four times at intervals of 7 days, collecting a splenocyte after the final immunization, fusing the splenocyte with a mouse myeloma cell, selecting a strain to produce a macrophage cell binding antibody from the obtained hybridoma and culturing the strain.;COPYRIGHT: (C)1999,JPO