ANTIBODY AGAINST GLYCOPROTEIN LIGAND HAVING BOND SPECIFIC FOR GMP-140

摘要

PROBLEM TO BE SOLVED: To obtain an antibody against a glycoprotein having a bond specific for GMP-140. SOLUTION: This glycoprotein ligand contains a fucosylated sialylated glycoprotein containing a sialyl Lex moiety and has about 120,000 apparent relative molecular weight by evaluation according to a sodium dodecyl sulfate- polyaceylamide get electrophoresis (SDS-PAGE) under reducing conditions. The antibody is effective in specifically blocking the bond of granule membrane protein-140 (GMP-140) to the glycoprotein ligand for the GMP-140.