ANTIBODY AGAINST GLYCOPROTEIN LIGAND HAVING SPECIFIC BOND TO GMP-140

摘要

PPROBLEM TO BE SOLVED: To provide an antibody against glycoprotein ligand having a specific bond to GMP (granule membrane protein)-140. PSOLUTION: The antibody against the glycoprotein ligand having the specific bond to the GMP-140 is provided. The glycoprotein ligand contains a fucosylated sialylated glycoprotein containing a sialyl part LeSPX/SP, and has about 120,000 apparent relative molecular weight when evaluated by SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis) under a reduction condition. The antibody is effective for specifically blocking the bond of the GMP-140 to the glycoprotein ligand against the GMP-140. PCOPYRIGHT: (C)2005,JPO&NCIPI