Anti- hyperlipemia symptom medicine and anti- artery muscardine medicine

摘要

PURPOSE: To provide a new pharmaceutical preparation which contains a specific imidazole compound as an active ingredient to lower the serum cholesterol and inhibit macrophage from being foamed. ;CONSTITUTION: A compound of formula I through formula III [R₁ is H, alkyl, aryl, mercapto, alkylthio, alkenylthio, arylthio, heterocyclic group; R₂ is H, alkyl which may be substituted with OH; R₃, R₄ are H, halogen, NO₂, R₅O, R₅CONH, R₅NHCO, (R₅)₂NCO, (R₅)SO₂NH, R₅NHSO₂, R₅OCO, R₅COO, R₅ NHCONH (R₅ is alkyl, aryl); R₆ is a divalent group] or its pharmaceutically permissible salt, for example, 2-methyl-5-nitrobenzimidazole, 1,8-bis(5- nitrobenzimidazol-2-yl)octane is contained as an active ingredient.;COPYRIGHT: (C)1994,JPO&Japio