PURPOSE:To obtain a safe and readily handleable preparation with hardly any irritation by condensing an acid halide with vanillylamine in a solvent, the dispersing the resultant capsaicins in water in a reaction bath thereof and subsequently converting the dispersion into oil-in-water type microcapsules. CONSTITUTION:A compound expressed by formula I (R is 4-12C alkyl, alkenyl or alkynyl; Hal is halogen), e.g. pelargonic acid chloride is condensed with vanillylamine or a salt thereof in a solvent, as necessary, in the presence of an acid binder to provide a compound expressed by formula II, e.g. N-(4- hydroxy-2-methoxybenzyl)-nonanamide, which is then directly dispersed in water in a reaction bath thereof and further subjected to an oil-in-water type polymerization method such as an interfacial polymerization method or in-situ polymerization method to afford a microcapsule pharmaceutical preparation of capsaicins. Thereby, the objective preparation with hardly any irritation can be obtained by starting from raw materials with hardly any irritation, without any contact of workers engaged in production thereof in spite of the strong irritating property of capsaicins.
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