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Production modulo of the glycoproteins of HCMV, the antibodies and the HCMV vaccine for those, and rearrangement vector null for
Production modulo of the glycoproteins of HCMV, the antibodies and the HCMV vaccine for those, and rearrangement vector null for
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机译:HCMV糖蛋白,这些抗体和HCMV疫苗的糖蛋白的生产模数,而对于
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摘要
HCMV glycoproteins B and H have been identified. The gB protein is encoded by DNA in the HindIII F fragment of the HCMV genome lying between 1378 and 4095 bases from the F/D boundary. The gH protein is encoded by DNA in the HindIII L fragment lying between 228 and 2456 bases from the L/D boundary. The genes have been incorporated in recombinant vaccinia vectors and expressed in host animals to raise HCMV-neutralising antibody, thereby indicating vaccine potential. The glycoproteins can also be used in a variety of different ways, as vaccines or in the production, purification or detection of HCMV antibody.
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