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Camptothecin analogue compound process for preparing product compounds industry medicines pharmaceutical compositions and product use
Camptothecin analogue compound process for preparing product compounds industry medicines pharmaceutical compositions and product use
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机译:喜树碱类似物化合物的制备方法,用于制备产品化合物,工业药物,药物组合物和产品用途
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摘要
Camptothecin analogues where the camptothecin hydroxy lactone is: (i) a beta -hydroxy lactone; or (ii) the corresp. beta -hydroxy acid resulting from ring-opening of the aforementioned lactone; or a (iii) deriv. of the beta -hydroxy acid in (ii) or its one of its salts. Also claimed are new industrial prods. of formula (M) and (A). R1 = lower alkyl, lower alkenyl, lower alkynyl, halo(lower alkyl), lower alkoxy(lower alkyl) or lower alkylthio(lower alkyl); R20 = H or halo; R22 = F, Cl, or lower alkoxy; R23 = prim. hydroxy-protecting gp.; and R18, R19 = H, halo, lower alkyl, lower alkoxy or OH.
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