Compound processes for the preparation of it and stop treatment of nausea or emesis medicine antiemetic agent pharmaceutical composition and use of the compound

摘要

This invention discloses a compound which is expressed by formula (I) below: CHEM or physiologically acceptable acid addition salts thereof. The claimed compound exhibits excellent antiemetic effect based on its potent serotonin S3 and dopamine D2 receptor antagonistic activities, and is useful for treatment or prophylaxis of various gastrointestinal symptoms which are associated with various diseases and drug administration.