Pharmaceutical composition useful for the transfection of at least one nucleic acid using this composition and a compound associating DNA fixation properties with a nu clear vectorization capacity of this DNA

摘要

PCT No. PCT/FR96/01516 Sec. 371 Date Mar. 27, 1998 Sec. 102(e) Date Mar. 27, 1998 PCT Filed Sep. 27, 1996 PCT Pub. No. WO97/12051 PCT Pub. Date Apr. 3, 1997A pharmaceutical composition useful for nucleic acid transfection is disclosed. The composition contains, in addition to a nucleic acid and at least one transfection agent, at least one compound that combines DNA binding properties with a nuclear DNA vectorisation capability, and preferably belongs to the HMG ("High mobility group") protein family. The use of said composition for in vitro, ex vivo and/or in vivo nucleic acid transfer is also disclosed.