In opiatagonistas Kappa - quality drugs for the treatment of inflammatory bowel Diseases

摘要

Drugs characterized by general formula refer to AR, i.e. 3 to 7 c-cyclo-a or 4 to 8 c-cyclo-a-carat; R2,AR, again 1,With R2 for 3 means h, oh, OA or a, R4,A or phenyl was eventually replaced by Hal once or twice Oh, OA, CF3,No...NH2,HNA NHCOA NHASO2 A o NA2 R5Ha ha, CH2 Oh, R6 and R7 are independent, which means h, Hal, oh, OA, CF3,NH2,NHA, NA2,NHCOA, NHCONH2,No2 or methylenedioxy; a refers to 1 to 7 C-atom tar; AR, an aromatic, single or double ring residue, which may contain n or u atoms, and replace 1, 2 or 3 times with a, Hal, oh, OA, CF3,NH2,NHA, NA2,Nhcoa and / or nhconh2; D, CH2,O S NH NA -CH2 -CH2 --CH = CH, -CH2 -NH-,Ch2-na, or a bond, and Hal, F, Cl, Br or I, but N-methyl-N hydrochloric acid [(1s) - 1-phenyl-2 - ((35) - 3-hydroxypyridine-1-il) - ethyl] - 2, 2-diphenyl-acetyl.