IMMUNOLOGICAL METHOD FOR DETECTING ANTIBODIES AGAINST TISSUE TRANSGLUTINAMINASE (tGT), APPLICATION OF tGT IN DIAGNOSTICS AND THERAPY CHECKING AS WELL AS ORAL PHARMACEUTICAL PREPARATION CONTAINING tGT

摘要

The invention relates to a method for detecting antibodies from body fluids by means of an immune reaction with tissue transglutaminase (tTG), with tTG-containing compounds, the antigenic structures, immunoreactive sequences or analogues thereof. The method may be used in the diagnosis and therapy control of diseases associated with an immune reaction against tTG, tTG-containing compounds, the antigenic structures, immunoreactive sequences or analogues thereof. Therefore, the invention is also directed to the use of tTG and the above-mentioned substances in diagnosis and therapy control, preferably in the diagnosis and therapy control of chronically inflammatory diseases or autoimmune diseases, and more preferably, in the diagnosis and therapy control of sprue or coeliac disease.