DERIVATIVE OF 2-PHENYL-3-AROYLBENZOTHIOPHENE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVATE FOR PREPARING PHARMACEUTICAL COMPOSITION INTENDED FOR INCREASE IN EFFICIENCY OF CONSTRICTORS

摘要

A method of increasing sphincter competence comprising administering to a human in need of treatment an effective amount of a compound having formula (I), wherein R1 and R3 are independently hydrogen, -CH3, (a) or (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidino, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof. Also encompassed by the invention is a method of inhibiting urinary or fecal incontinence, or gastroesophageal disease or its symptoms, which includes administering to a human in need thereof an effective amount of a compound of formula (I).