INDUSTRIAL PRODUCT, ANTAGONIST OF INTEGRIN ALPHAv BETA3, PHARMACEUTICAL PREPARATION CONTAINING ALPHAv BETA3 ANTAGONIST AND INHIBITION METHOD OF ANGIOGENESIS IN TISSUE

摘要

The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin alpha v beta 5 antagonists. The alpha v beta 5-mediated angiogenesis is correlated with exposure to cytokines including vascular endothelial growth factor, transforming growth factor- alpha and epidermal growth factor. Inhibition of alpha v beta 5-mediated angiogenesis is particularly preferred in vascular endothelial ocular neovascular diseases, in tumor growth and in inflammatory conditions, using therapeutic compositions containing alpha v beta 5 antagonists.