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Solid dispersion type tablets containing 1,4-dihydropyridine derivatives and process for the preparation of seed
Solid dispersion type tablets containing 1,4-dihydropyridine derivatives and process for the preparation of seed
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机译:包含1,4-二氢吡啶衍生物的固体分散型片剂及其制备方法
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摘要
The present invention relates to a pharmaceutical solid dispersion tablet comprising a solid dispersion material (a) which comprises a substantially water-insoluble 1,4-dihydropyridine derivative as pharmaceutical active agent represented by the general formula [I]: CHEM wherein Ar is a substituted aryl or benzofurazanyl group, R1 is a substituted or unsubstituted alkyl group, R2 is a substituted or unsubstituted alkyl or alkenyl group or a substituted piperidyl group, R3 and R4 each independently represent a substituted or unsubstituted alkyl group, and the substituent R1OCO- at the 5-position may be replaced by a dialkylphosphonoate or alkylene dioxyphosphoryl group, or a pharmaceutically acceptable acid addition salt thereof and hydroxypropyl cellulose; and a solid dispersion material (b) which comprises said 1,4-dihydropyridine derivative or its pharmaceutically acceptable acid addition salt and hydroxypropyl methyl cellulose phthalate. The present invention also relates to a process for preparing the above solid dispersion tablets.
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机译:药物固体分散片技术领域本发明涉及一种药物固体分散片,其包含固体分散材料(a),所述固体分散材料包含基本上不溶于水的1,4-二氢吡啶衍生物作为由通式[I]表示的药物活性剂: R 1是取代的或未取代的烷基,R 1是取代或未取代的烷基或烯基或取代的哌啶基,R 3和R 4各自独立地表示:取代或未取代的烷基,且在5-位的取代基R 1 OCO-可被二烷基膦酸酯或亚烷基二氧基磷酰基或其药学上可接受的酸加成盐和羟丙基纤维素取代;固体分散体材料(b),其包含所述1,4-二氢吡啶衍生物或其药学上可接受的酸加成盐和羟丙基甲基纤维素邻苯二甲酸酯。本发明还涉及制备上述固体分散体片剂的方法。
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