A process for the preparation of therapeutically useful benzylg / indole-2,3-dione-3-hydrazone derivatives and 6,7,8,9-tetrahydrobenzylgindole-2,3-dione hydrazone derivatives

摘要

A method of treatment with compounds having the formula CHEM wherein n is 0 or 1; R1 is hydrogen, C1-6-alkyl which may be branched, C3-7-cycloalkyl, benzyl, phenyl which may be substituted, acyl, hydroxy, C1-6-alkoxy, CH2CO2R' wherein R' is hydrogen or C1-6-alkyl which may be branched, CH2CN, CH2CONRIVRV wherein RIV and RV independently are hydrogen or C1-6-alkyl, or CH2C(=NOH)NH2; R2 is pyridyl or phenyl, both of which may be substituted one or more times preferably in the ortho and para positions with halogen, CF3, NO2, CN, phenyl, SO2NR''R''' wherein R'' and R''' independently are hydrogen, benzyl, or C1-6-alkyl; R4, R5, R6, R7 independently are hydrogen, C1-6-alkyl which may be branched, phenyl, halogen, C1-6-alkoxy, NO2, CN, CF3, or SO2NR11R12 wherein R11 and R12 independently are hydrogen, benzyl, or C1-6-alkyl; or R6 and R7 together form an additional 4 to 8 membered carbocyclic ring which may be aromatic or partial saturated and which may be substituted with halogen, NO2, CF3, CN, SO2NR13R14 wherein R13 and R14 independently are hydrogen, benzyl, or C1-6-alkyl, and R4 and R5 have the meanings set forth above; or R4 and R5 together form an additional 4 to 8 membered carbocyclic ring which may be aromatic or partial saturated and which may be substituted with halogen, NO2, CF3, CN, SO2NR13R14 wherein R13 and R14 independently are hydrogen, benzyl, or C1-6-alkyl, and R6 and R7 have the meanings set forth above. Certain of the compounds are novel. The compounds and pharmaceutical compositions containing the compounds are useful in the treatment of central nervous system disorders and especially conditions sensitive to excitatory amino acids.