首页> 外国专利> METHOD FOR NEUTRALISING CHEMICAL WARFARE MUSTARD GASES, SARIN, AND SKIN ERYTHEMA FROM ULTRAVIOLET RADIATION OF THE SUN BY THE USE OF FREE RADICAL INHIBITORS

METHOD FOR NEUTRALISING CHEMICAL WARFARE MUSTARD GASES, SARIN, AND SKIN ERYTHEMA FROM ULTRAVIOLET RADIATION OF THE SUN BY THE USE OF FREE RADICAL INHIBITORS

机译:通过自由基抑制剂对太阳紫外线辐射化学中的芥子气,沙林和皮肤红斑进行中和的方法

摘要

The invention describes a method of withholding and neutralising chemical warfare mustard gases and the chemical warfare nerve gas, sarin, on the skin, the use of enzyme inhibitors and antioxidant substances that inhibit manifestations of these gases on the skin such as erythema and burning, the inhibition of solar erythema and burning and the creation of carcinogenic nitroso compounds by the ultraviolet radiation of the sun as well as the use, in the form of an aerosol, of antioxidant substances, neutralisers of the free radicals that are created by the burning of forests, houses etc. and enter the lungs on inhalation. These methods are characterised by the use of an ointment or cream that contains active biological substances capable of producing hydroxyl radicals (OH) that deactivate mustard gases, biological compounds that bind mustard gases (e.g. DNA) or compounds of iron or of another displacement metal in the form of haeme or stereochemically bound to protein that can be hydroxylated (e.g. haematin) so as to be able to react with organophosphorus compounds such as sarin and inhibit their absorption by the skin.
机译:本发明描述了一种在皮肤上抑制和中和化学战芥子气和化学战神经毒气沙林的方法,使用酶抑制剂和抗氧化剂来抑制这些气体在皮肤上的表现,例如红斑和灼伤,抑制太阳红斑和燃烧,以及通过太阳紫外线辐射产生致癌的亚硝基化合物,以及以气雾剂形式使用抗氧化剂,以及由森林燃烧产生的自由基的中和剂,房屋等,并通过吸入进入肺部。这些方法的特点是使用的软膏或乳膏含有能够产生使芥子气失活的羟基自由基(OH)的活性生物物质,与芥子气结合的生物化合物(例如DNA)或铁或其他置换金属的化合物。血红素的形式或立体化学结合到可以被羟基化的蛋白质(例如血红素)上,从而能够与有机磷化合物(如沙林)反应并抑制其被皮肤吸收。

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