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PROCESS FOR PREPARATION OF 2,4,6-TRIMETHYL-PHENYLACETIC ACID
PROCESS FOR PREPARATION OF 2,4,6-TRIMETHYL-PHENYLACETIC ACID
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机译:制备2,4,6-三甲基-苯乙酸的方法
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摘要
The present invention relates to a process for the preparation of 2,4,6-trimethylphenylacetic acid of formula (5). According to the invention, a hydroxyacetic acid derivative of the general formula (II) activated with a sulphonyloxyxyl moiety, wherein R1 is cyano, carboxy, methoxycarbonyl, ethoxycarbonyl or R-oxyloxy, means a halogen atom, an alkyl, halogen alkyl or optionally substituted phenyl or benzyl tube, optionally a diluent, and 1,3,5-trimethyl in the presence of 2.3 to 4.0 moles of Lewis acid, based on the compound of formula (II). they are reacted with benzene and, if desired, hydrolyzed to the resulting product. ŕ
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