PROCESS FOR PREPARING PROSTAGLANDIN E1, E2 AND ANALOGS THEREOF USING FURYLCOPPER REAGENTS

摘要

the object of the invention is the procedure pru0151sztaglandin e1, e2 and szu00e1rmazu00e9kaikszintetiku0171s production.the procedure, egyedu00e9nyes "reaction, ahu0151l 2 - fu0171ril lu00edtiu0171mu0151t cianidu0151t -, copper -,short chain alkyl lu00edtiu0171m reagent, and (e) - alkenil - sztannu00e1nt or (ii) a halu0151genidet reagu00e1ltatnak u00e1ltalu00e1nu0151sku00e9pletu0171 - ahu0151l (xa, xb) or the report of u00e1ltalu00e1nu0151s csu0151pu0151rt) formula.within the meaning of hidru0151gu00e9natu0151m r5, tetrahkidru0151piranil, tetrahidru0151fu0171ranil, short chain trialkyl silyl -, 1 - methyl - 1 - ethyl - metu0151xi,1 - methyl - 1 - ethyl - or etu0151xi csu0151pu0151rt - (co) - u00e1ltalu00e1nu0151sku00e9pletu0171 csu0151pu0151rt r8 r8, within which the report hidru0151gu00e9natu0151m, ru00f6vidszu00e9nlu00e1ncu00fa alkilcsu0151pu0151rt or halu0151gu00e9nezett, short szu00e9nlu00e1ncu00faalkilcsu0151pu0151rt,report of ethylene or vinilu00e9ncsu0151pu0151rt r6 and r5 r7jelentu00e9se csu0151pu0151rt, short chain alkyl or a short szu00e9nlu00e1ncu00faalkenilcsu0151pu0151rt - ciklu0151pentanu0151nnal.the desired pru0151sztaglandint is greater than or equal to 80% of the ancient hu0151zammal kapju00e1kmeg. a