Effect of prostaglandin E1 combined with Xuebijing on the inflammatory response process and target organ function in patients with sepsis

摘要

Objective: To explore the effect of prostaglandin E1 combined with Xuebijing on the inflammatory response process and target organ function in patients with sepsis. Methods: A total of 78 patients with sepsis who were treated in our hospital between February 2014 and July 2017 were divided into control group (n=39) and study group (n=39) by random number table method. Control group received Xuebijing therapy on the basis of routine treatment, and study group received prostaglandin E1 combined with Xuebijing therapy on the basis of routine treatment. The differences in serum levels of inflammatory mediators and target organ function indexes were compared between the two groups before treatment (T0), after 1 week of treatment (T1) and after 2 weeks of treatment (T2). Results: At T0, there was no statistically significant difference in the serum levels of inflammatory mediators, myocardial enzyme spectrum indexes as well as liver and kidney function indexes between the two groups. At T1 and T2, serum inflammatory mediators IL-6, IL-10, PCT and CRP levels of study group were lower than those of control group;serum myocardial enzyme spectrum indexes CK-MB, hs-cTnT and LDH contents were lower than those of control group;serum liver and kidney function indexes BUN, Cr, TBIL and TBA contents were lower than those of control group. Conclusion: prostaglandin E1 combined with Xuebijing can effectively reduce the systemic inflammatory response and actively protect the liver and kidney function of patients with sepsis.