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Blanding med bestemt dose, av en angiotensinkonverterende enzyminhibitor og en kalsiumkanal antagonist, fremgangsmÕte for fremstilling og anvendelse derav i behandling av kardiovaskulµre sykdommer
Blanding med bestemt dose, av en angiotensinkonverterende enzyminhibitor og en kalsiumkanal antagonist, fremgangsmÕte for fremstilling og anvendelse derav i behandling av kardiovaskulµre sykdommer
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机译:特定剂量的血管紧张素转化酶抑制剂和钙通道拮抗剂的混合物,其制备方法和用于治疗心血管疾病的方法
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摘要
Fixed-dose association of an ACE inhibitor and an antagonist of calcium channels, process for their preparation and their use for the treatment of cardiovascular diseases. Comprising (a) enalapril or nitrendipine pharmaceutically acceptable salt thereof and (b) or a pharmaceutically acceptable salt thereof, is administered in dosage unit dosage form. The method comprises: a) dissolving enalapril in water with an inorganic salt, b) mixing the nitrendipine with a fraction of the disintegrating excipients, wetting agent, fragmentary diluent, binder and plastic diluent, previously sieved, c) granulating the mixture of paragraph (b) with the solution obtained in (a); (D) drying the granulated mass, (e) incorporating the lubricating agent and the remaining fraction of excipients and homogenizing the calibrated granulate; (F) compressing the granulate. Use of said association for the manufacture of a medicament for the treatment of diseases of the cardiovascular system.
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