Sulfonamidsubstituerte kondenserte 5-ringforbindelser, deres anvendelse som medikament samt farmas°ytiske preparater inneholdende forbindelsene

摘要

3-Sulfonamido-indene, benzofuran, indole or benzothiophene derivatives (I) are new. Sulfonamides of formula (I) and their salts are new: X = CR22R23, O, NR24, S, SO or SO2; R1,R2 = H, CF3 or alkyl; R2 may also = OR10a if X = CR22R23; R9 = H; or R2 + R9 = bond; R10a = H, acetyl or 1-3C alkyl; R3 = R10b-CnH2n-N(R11) or R10b-CnH2n (in which one CH2 of CnH2n is optionally replaced by O, CO, S, SO, SO2 or NR12a); R4 = R13-CrH2r (in which one CH2 of CrH2r is optionally replaced by O, CH=CH, C equivalent to C, CO, COO, OCO, S, SO, SO2, NR14 or CONR14); or R3 + R4 = 3-8C alkylene (in which one CH2 is optionally replaced by O, CO, S, SO, SO2 or NR12a); n = 0-10; r = 0-20; R12a = H, Me or Et; R10b = Me, cycloalkyl, CF3, C2F5 or C3F7; R11 = H or alkyl; or or R10b + R11 = bond if n = 3-10; R14 = H, 1-3C alkyl, CyH2yOR12b or CyH2yN(R12b)2; R12b = H, Me or Et; y = 2 or 3; R13 = Me, CF3, C2F5, C3F7, cycloalkyl, NR15R16, CONR15R16, OR17 or COOR17; or phenyl or 1-9C N-containing heterocycle (both optionally mono- or disubstituted by Q); Q = F, Cl, Br, I, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SONH2, SO2Me or NHSO2Me; R15,R16 = H or 1-4C alkyl; or R15+R16 = (CH2)4 or (CH2)5 (in which one CH2 is optionally replaced by O, S, NH, NMe or N(CH2Ph)); R17 = H, 1-3C alkyl or CzH2zR12c; R12c = H, Me or Et; z = 2 or 3; R5-R8 = H, F, Cl, Br, I, 1-5C alkyl, cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2 or -Y-CsH2s-R18; or phenyl, thienyl, furyl or 1-9C N-containing heterocycle (all optionally mono- or disubstituted by Q); Y = O, CO, COO, OCO, S, SO, SO2, OSO2, SO2NR10c or CONR10c (all bonded to the basic structure via the left-hand atom); R10c = H or 1-3C alkyl; s = 1-6; R18 = H, Me, CF3, C2F5, cycloalkyl, OR21, COOR21, NR15R16 or CONR15R16; or phenyl or 1-9C N-containing heterocycle (both optionally mono- or disubstituted by Q); R21 = H or 1-3C alkyl; R22,R23 = H, CF3 or alkyl; R24 = H, alkyl or phenyl (optionally mono- or disubstituted by Q); and alkyl moities = 1-6C and cycloalkyl 3-8C unless specified otherwise.